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Background
Contradictory data have been reported about the association between testosterone levels and the levels of low‐density lipoprotein cholesterol (LDL).
Objectives
The aim of this study was to elucidate the association between testosterone and LDL levels.
Materials and methods
A cross‐sectional study was conducted that included 7268 men who had participated in a health examination. Men...
Background
The level of education has been recognized as a cardiovascular risk factor; nevertheless, it is often neglected in cardiovascular risk prediction.
Objectives
To evaluate the psychobiological correlates of the level of education and if it could predict incident major adverse cardiovascular events in men consulting for erectile dysfunction.
Methods
Total 3733 men (49.8 ± 13.7 years old)...
Objective
To investigate the potential association between paternal health and male genital malformations in the offspring.
Materials and methods
We analyzed data from 2007 to 2016 derived from the IBM MarketScan Research database, which reports on reimbursed private healthcare claims in the United States. The association between paternal comorbidities (defined as individual and combined measures)...
Background
The development of single‐cell sequencing technology has expanded the understanding of cell heterogeneity and disease progression in the male genitourinary system. However, complex processing and unprofessional analytical annotations limit the daily use and widely sharing of published datasets.
Objectives
Single‐cell sequencing data of male‐specific tissues and organs.
Materials and...
Background
Recently, dapoxetine has been widely accepted to treat premature ejaculation by fast‐inhibiting 5‐hydroxytryptamine reuptake. However, dapoxetine is not suitable for all premature ejaculation patients in clinical treatment. We need to investigate and reveal the mechanism deeply to solve this problem.
Objectives
To investigate and reveal the function of dopamine D4 receptor in dapoxetine...
Background
Oligoasthenoteratozoospermia (OAT) is one of the most complex aggregators of male gametic problems. However, the genetic etiology of OAT is still largely unknown.
Objectives
To reveal the new genetic factors responsible for male infertility owning to OAT and reveal the outcomes of the affected patients from intracytoplasmic sperm injection (ICSI).
Materials and methods
Two infertile...
Background
Sexual dysfunctions, particularly erectile dysfunction, are common in men living with HIV, whose organic and psychological components remain to be clarified. The aim of the study is to investigate the impact of risk factors of sexual dysfunctions, including organic, relational, and psychological determinants of erectile function, in men living with HIV younger than 50 years old.
Methods...
Background
Seminal vesiculitis is a common inflammation in the male genital tract. Etiologically, microbial infection and non‐infectious factors can be responsible for seminal vesiculitis. The pathogenic triggers and mechanisms underlying non‐infectious seminal vesiculitis remain unclear.
Objectives
To demonstrate that spermatozoa can induce seminal vesiculitis in mice, which could be attributable...
Background
The application of fertility preservation, initially intended for oncological patients prior to gonadotoxic treatment, has extended in recent years to transgender and gender‐non‐conforming individuals undergoing therapy for gender compatibility.
Objectives
To examine semen quality and survival in transgender women pursuing semen cryopreservation in the presence or absence of gender‐affirming...
Background
The sperm retrieval rate of microdissection testicular sperm extraction varies from 25% to 60%. Therefore, it is necessary to establish objective selection criteria for identifying seminiferous tubules with spermatozoa.
Objectives
Our aim was to develop a method for identifying spermatogenesis without sectioning testicular tissues.
Materials and methods
Testicular tissues of 10‐week‐old...
Background
Increasing preconception paternal comorbidity has been associated with adverse pregnancy outcomes. However, whether the father's health impacts the child after birth is uncertain.
Objectives
In the present study, we examined the association of preconception paternal metabolic syndrome status with childhood emergency department visits and hospitalizations.
Materials and Methods
This...
Background
The increase in paternal age and the percentage of births after assisted reproductive technologies (ART) may have consequences on offspring and society's position regarding access to ART must be questioned. Most countries recommend limiting ART to men under 60 years. What is the rationale for this threshold?
Objective
This systematic review assesses scientific arguments to establish...
Background
Although selective estrogen receptor modulators have been proposed as a treatment for men with central functional hypogonadism, only a few data have been produced in men with obesity‐related functional androgen deficiency.
Objective
To determine whether and to what extent selective estrogen receptor modulators are an effective and safe therapy in men with obesity‐related functional androgen...
Aquaporins—small, “unusual” proteins, whose discovery revolutionized the view of membrane transport of water and other small molecules, are essential for all living organisms. Aquaporins located in the male reproductive system seem to play a key role in the proper course of many processes occurring within it, thus maintaining a high reproductive potential.
Background
Apo A‐I Leu75Pro amyloidosis is a rare systemic hereditary disease, whose hallmark and earliest involvement is testicular impairment, characterized by hypogonadism and macrorchidism; renal and hepatic involvement are the other characteristics.
Objective
To evaluate for the first time the prevalence of osteopenia, osteoporosis and vertebral fractures (VFs) in men with this form of amyloidosis...
Background
Male infertility is a prevalent and worldwide problem with various difficulties in treatment. Clomiphene citrate is a selective estrogen receptor modulator and may improve semen quality by stimulating hormone synthesis and spermatogenesis. There is lack of evidence on the efficacy of clomiphene citrate as therapy for male infertility.
Objectives
Therefore, a systematic review and meta‐analysis...
Background
Rabbits are sensitive to dietary cholesterol and rapidly develop hypercholesterolemia, leading to prominent subfertility. Sterol regulatory element‐binding protein isoform 2 drives the intracellular cholesterol pathway in many tissues, including the testicles. Its abnormal regulation could be the mainly responsible for the failure of suppressing cholesterol synthesis in a cholesterol‐enriched...
Background
Prostate biopsy represents one of the most frequently performed urologic procedures worldwide and therefore presupposes knowledge on potential effects like on the erectile function, especially in extensive or repeated biopsies. The robotic‐assisted biopsy system (Mona Lisa) offers a minimal invasive approach via only two incision points ensuring maximal accuracy combined with protection...
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